MGF (mekanik büyüme faktörü) vücut geliştiriciler ve sporcular tarafından birkaç yıldır kullanılıyor. Direnç egzersizi sonrası, IGF-1 kas içinde salınır. özellikle, Şu anda, Bir kasın mekanik kullanımının hemen ardından, IGF-I geni, hipertrofiyi ve lokal kas hasarının onarımını başlatan MGF'ye bağlanır. It does so both by activating muscle stem cells and satellite cells, but also via various other anabolic processes. It differs from “regular” IGF-1 mainly due to it’s C-Terminal sequence.
In a rodent study, a single intramuscular injection into muscle resulted in a 25% increase in mean muscle fibre cross section area within three weeks.Using a similar protocol, liver-derived IGF-1 took four months to produce a 15% increase.
It would also appear that with regards to age, the young have a better ability to respond to MGF, and that the elderly experience a decreased response to MGF which results in a decreased ability to stimulate the growth of new muscle tissue.