Sildenafil mesilato Cas:131543-23-2

Uso: Matérias-primas farmacêuticas, afrodisíaco É matéria-prima para tratamento de medicamentos, indicado para o tratamento da disfunção erétil.

Mesilato de Sildenafila, assim como o Sildenafil é um inibidor do tipo 5 -cGMP fosfodiesterase relaxa e suaviza as células musculares do corpo cavernoso, o que leva à ereção peniana. Este relaxamento pode ser mediado pelo óxido nítrico via monofosfato de guanosina cíclico.material farmacêutico, hormônio. As a cyclic guanosine monophosphate (cGMP) specific phosphodiesterase type 5 (PDE5) selective inhibitor, penile smooth muscle relaxation allows rapid erection. Sildenafil is cheap, is the development and production of low-cost classes available kidney yang-like the perfect material for medicine and health products.

Em 16 separate 4-24 week trials of men (over 18 anos) who suffered from impotence for longer than 6 meses, dosages between 10-200 mgs were administered. Significant improvements in erectile function, including frequency of penetration as well as erection duration post penetration, were reported with Sildenfi* treatment compared to the placebo group.

Erections were improved in 72% of group verses 18% of the placebo group. In all cases effects were dependant upon dosage and improvement was the greatest when dosage exceeded 100 mgs. Responses were decreased by 40-60% in patients suffering from diabetes and prostatectomy, respectivamente. Withdrawal rates were less than 5% related to negative side effects and limited response rates.