Mésylate de sildénafil
CAS: 131543-23-2
MF: C28H30N2O6S
MW: 522.6126
Boiling point: 627.7 ° C at 760 MMHG
Flash Point: 333.4 ° C
Pression de vapeur: 1.14E-15mmHg at 25 ° C
Propriétés:Solubility: 0.1 M HCl: 0.25 mg / mL
Apparence: White or white crystalline powder, odorless, bitter astringent taste, soluble in water and ethanol
Usage: Matières premières pharmaceutiques, aphrodisiaque C'est une matière première de traitement médical, indiqué pour le traitement de la dysfonction érectile.
Mésylate de sildénafil, tout comme le Sildénafil, c'est un inhibiteur de type 5 -phosphodiestérase GMPc relaxant et lissant les cellules musculaires des corps caverneux, ce qui conduit à l'érection du pénis. Cette relaxation peut être médiée par l'oxyde nitrique via le monophosphate de guanosine cyclique.matériel pharmaceutique, hormone. As a cyclic guanosine monophosphate (cGMP) specific phosphodiesterase type 5 (PDE5) selective inhibitor, penile smooth muscle relaxation allows rapid erection. Sildenafil is cheap, is the development and production of low-cost classes available kidney yang-like the perfect material for medicine and health products.
In 16 separate 4-24 week trials of men (over 18 years old) who suffered from impotence for longer than 6 mois, dosages between 10-200 mgs were administered. Significant improvements in erectile function, including frequency of penetration as well as erection duration post penetration, were reported with Sildenfi* treatment compared to the placebo group.
Erections were improved in 72% of group verses 18% of the placebo group. In all cases effects were dependant upon dosage and improvement was the greatest when dosage exceeded 100 mgs. Responses were decreased by 40-60% in patients suffering from diabetes and prostatectomy, respectivement. Withdrawal rates were less than 5% related to negative side effects and limited response rates.
