Силденафила Мезилат
КАС: 131543-23-2
МФ: C28H30N2O6S
МВт: 522.6126
Boiling point: 627.7 °С при 760 мм рт.ст.
Точка возгорания: 333.4 °С
Vapor Pressure: 1.14E-15mmHg at 25 °С
Характеристики:Растворимость: 0.1 M HCl: 0.25 мг / mL
вид: White or white crystalline powder, odorless, bitter astringent taste, soluble in water and ethanol
Применение: Фармацевтическое сырье, афродизиак. Это лекарственное сырье., показан для лечения эректильной дисфункции.
Силденафила Мезилат, так же, как Силденафил, является ингибитором типа 5 -цГМФ-фосфодиэстераза расслабляет и разглаживает мышечные клетки кавернозного тела, что приводит к эрекции полового члена.. Эта релаксация может быть опосредована оксидом азота через циклический гуанозинмонофосфат. Фармацевтический материал., гормон. As a cyclic guanosine monophosphate (cGMP) specific phosphodiesterase type 5 (ФДЭ5) selective inhibitor, penile smooth muscle relaxation allows rapid erection. Sildenafil is cheap, is the development and production of low-cost classes available kidney yang-like the perfect material for medicine and health products.
В 16 separate 4-24 week trials of men (над 18 лет) who suffered from impotence for longer than 6 месяцы, dosages between 10-200 mgs were administered. Significant improvements in erectile function, including frequency of penetration as well as erection duration post penetration, were reported with Sildenfi* treatment compared to the placebo group.
Erections were improved in 72% of group verses 18% of the placebo group. In all cases effects were dependant upon dosage and improvement was the greatest when dosage exceeded 100 mgs. Responses were decreased by 40-60% in patients suffering from diabetes and prostatectomy, respectively. Withdrawal rates were less than 5% related to negative side effects and limited response rates.
