Acétate de goséréline CAS:145781-92-6

Informations sur le produit:

1. Gonadorelin est un autre nom pour l'hormone de libération des gonadotrophines (GnRH). Il s'agit d'un décapeptide synthétique préparé par synthèse peptidique en phase solide.. La GnRH est responsable de la libération de l'hormone folliculo-stimulante et de l'hormone lutéinisante par l'hypophyse antérieure..

2. La GnRH est disponible sous forme de chlorhydrate de gonadoreline )et diacétate de gonadoréline tétrahydraté pour usage injectable. Studies have described it being used via an infusion pump system to induce ovulation in patients with hypothalamic hypogonadism. It is also used in veterinary medicine as a treatment for cattle with cystic ovarian disease.

3. Gonadorelin is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. In the pituitary GnRH stimulates synthesis and release of FSH and LH, a process that is controlled by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens.

The pulsatility of GnRH secretion has been seen in all vertebrates, and it is necessary to ensure a correct reproductive function. Thus a single hormone, GnRH, controls a complex process of follicular growth, ovulation, and corpus luteum maintenance in the female, and spermatogenesis in the male. Its short half life requires infusion pumps for its clinical use.