Goserelin Acetate
Cas No.: 145781-92-6
فرمول مولکولی: C61H88N18O16
وزن مولکولی: 1269.4
خلوص (HPLC): 98.0%دقیقه.
ظاهر: پودر سفید
Single Impurity (HPLC): 0.5%max
Amino Acid Composition: ±10% of theoretical
Peptide Content (N%): ≥80.0%
Water Content(Karl Fischer): ≤8.0%
Acetate Content(HPIC): ≤10.0%
اماس (ESI): Consistent
Mass Balance: 95.0~105.0%
اطلاعات محصول:
1. Gonadorelin نام دیگر هورمون آزاد کننده گنادوتروپین است (GnRH). این یک دکاپپتید مصنوعی است که با استفاده از سنتز پپتید فاز جامد تهیه می شود. GnRH مسئول ترشح هورمون محرک فولیکول و هورمون لوتینه کننده از هیپوفیز قدامی است..
2. GnRH به صورت گونادورلین هیدروکلراید موجود است )و گونادورلین دی استات تتراهیدرات برای استفاده تزریقی. Studies have described it being used via an infusion pump system to induce ovulation in patients with hypothalamic hypogonadism. It is also used in veterinary medicine as a treatment for cattle with cystic ovarian disease.
3. Gonadorelin is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. In the pituitary GnRH stimulates synthesis and release of FSH and LH, a process that is controlled by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens.
The pulsatility of GnRH secretion has been seen in all vertebrates, and it is necessary to ensure a correct reproductive function. Thus a single hormone, GnRH, controls a complex process of follicular growth, تخمک گذاری, and corpus luteum maintenance in the female, and spermatogenesis in the male. Its short half life requires infusion pumps for its clinical use.
