Goserelinacetat CAS:145781-92-6

Produktinformationen:

1. Gonadorelin ist ein anderer Name für Gonadotropin-Releasing-Hormon (GnRH). Es handelt sich um ein synthetisches Decapeptid, das mithilfe der Festphasenpeptidsynthese hergestellt wird. GnRH ist für die Freisetzung des follikelstimulierenden Hormons und des Leutinisierungshormons aus dem Hypophysenvorderlappen verantwortlich.

2. GnRH ist als Gonadorelinhydrochlorid erhältlich )und Gonadorelindiacetat-Tetrahydrat zur injizierbaren Anwendung. Studies have described it being used via an infusion pump system to induce ovulation in patients with hypothalamic hypogonadism. It is also used in veterinary medicine as a treatment for cattle with cystic ovarian disease.

3. Gonadorelin is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. In the pituitary GnRH stimulates synthesis and release of FSH and LH, a process that is controlled by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens.

The pulsatility of GnRH secretion has been seen in all vertebrates, and it is necessary to ensure a correct reproductive function. Thus a single hormone, GnRH, controls a complex process of follicular growth, Ovulation, and corpus luteum maintenance in the female, and spermatogenesis in the male. Its short half life requires infusion pumps for its clinical use.