Dapoksetin CAS:119356-77-3

Seçici bir serotonin geri alım inhibitörüdür. (SSRI) erken boşalma için özel olarak tasarlanmış. SSRI'ların PE tedavisinde etkili olduğu gösterilmiştir. Çoğu SSRI'nın dezavantajı, istenen etkiyi elde etmek için günlük olarak alınmalarının gerekli olmasıdır.. bir yere götürülmek üzere tasarlandı “gerektiği gibi” basis and has been shown to be effective when taken < 3 hours before sexual activity. Studies have shown that increases the intra-vaginal ejaculation latency time (IELTS'ler) – the time from vaginal penetration to male orgasm.

Erken boşalma tedavisi için özel olarak geliştirilmiş ilk bileşiktir. (PE) for men at th age of 18-64 yaşında. serotonin taşıyıcısını inhibe ederek çalışır, Sinaptik sonrası yarıkta serotoninin etkisini arttırmak, so as to delay ejaculation.. Seçici serotonin geri alım inhibitörünün bir üyesi olarak (SSRI) aile, was initially created as an antidepressant. Yine de, unlike other SSRIs, is absorbed and eliminated rapidly in the body. Its fast response makes it suitable for the treatment of PE but not as an antidepressant.

Treat male premature ejaculation and erectile dysfunction.Because lack of specific approval treatment for PE in the US and some other countries, other SSRIs such as fluoxetine, paroxetine, sertraline, fluvoxamine, and citalopram have been used as off label drugs to treat PE. Waldinger’s meta analysis shows that the use of these conventional antidepressants increasing IELT from two to ninefold above base line in comparison of three to eightfold when dapoxetine is used. Yine de, these SSRIs must be taken daily in order to achieve meaningful efficacy, and the long half-life increases the risk of the drug accumulation and as a consequence increased of adverse effects such as decreasing sexual libido and causing erectile dysfunction. Dapoxetine, diğer taraftan, is a fast-acting SSRI. It is rapidly absorbed and eliminated from the body within a few hours. This favorable pharmacokinetics minimizes the risk of the drug’s accumulation in the body, and therefore reducing side effects.