داپوکستین CAS:119356-77-3

این یک مهارکننده انتخابی بازجذب سروتونین است (SSRI) که به طور خاص برای انزال زودرس طراحی شده است. نشان داده شده است که SSRI ها برای درمان PE موثر هستند. نقطه ضعف بیشتر SSRI ها این است که برای دستیابی به اثر مطلوب باید روزانه مصرف شوند. طراحی شده بود تا روی یک “در صورت نیاز” basis and has been shown to be effective when taken < 3 hours before sexual activity. Studies have shown that increases the intra-vaginal ejaculation latency time (آیلتس) – the time from vaginal penetration to male orgasm.

این اولین ترکیبی است که به طور ویژه برای درمان انزال زودرس ساخته شده است (PE) for men at th age of 18-64 ساله. با مهار ناقل سروتونین کار می کند, افزایش عملکرد سروتونین در شکاف پس سیناپسی, so as to delay ejaculation.. به عنوان عضوی از مهارکننده های انتخابی بازجذب سروتونین (SSRI) خانواده, was initially created as an antidepressant. با این حال, unlike other SSRIs, is absorbed and eliminated rapidly in the body. Its fast response makes it suitable for the treatment of PE but not as an antidepressant.

Treat male premature ejaculation and erectile dysfunction.Because lack of specific approval treatment for PE in the US and some other countries, other SSRIs such as fluoxetine, paroxetine, sertraline, fluvoxamine, and citalopram have been used as off label drugs to treat PE. Waldinger’s meta analysis shows that the use of these conventional antidepressants increasing IELT from two to ninefold above base line in comparison of three to eightfold when dapoxetine is used. با این حال, these SSRIs must be taken daily in order to achieve meaningful efficacy, and the long half-life increases the risk of the drug accumulation and as a consequence increased of adverse effects such as decreasing sexual libido and causing erectile dysfunction. Dapoxetine, از سوی دیگر, is a fast-acting SSRI. It is rapidly absorbed and eliminated from the body within a few hours. This favorable pharmacokinetics minimizes the risk of the drug’s accumulation in the body, and therefore reducing side effects.