Dapoxetina CAS:119356-77-3

Es un inhibidor selectivo de la recaptación de serotonina (SSRI) que fue diseñado específicamente para la eyaculación prematura. Se ha demostrado que los ISRS son efectivos para el tratamiento de la educación física. La desventaja de la mayoría de los ISRS es que deben tomarse diariamente para lograr el efecto deseado. fue diseñado para ser tomado en un “según sea necesario” basis and has been shown to be effective when taken < 3 hours before sexual activity. Studies have shown that increases the intra-vaginal ejaculation latency time (IELTS) – the time from vaginal penetration to male orgasm.

Es el primer compuesto desarrollado especialmente para el tratamiento de la eyaculación prematura. (Orina) for men at th age of 18-64 años. trabaja inhibiendo el transportador de serotonina, Aumento de la acción de la serotonina en la hendidura post sináptica, so as to delay ejaculation.. Como miembro del inhibidor de la recaptación de serotonina selectiva (SSRI) familia, was initially created as an antidepressant. Sin embargo, unlike other SSRIs, is absorbed and eliminated rapidly in the body. Its fast response makes it suitable for the treatment of PE but not as an antidepressant.

Treat male premature ejaculation and erectile dysfunction.Because lack of specific approval treatment for PE in the US and some other countries, other SSRIs such as fluoxetine, paroxetine, sertraline, fluvoxamine, and citalopram have been used as off label drugs to treat PE. Waldinger’s meta analysis shows that the use of these conventional antidepressants increasing IELT from two to ninefold above base line in comparison of three to eightfold when dapoxetine is used. Sin embargo, these SSRIs must be taken daily in order to achieve meaningful efficacy, and the long half-life increases the risk of the drug accumulation and as a consequence increased of adverse effects such as decreasing sexual libido and causing erectile dysfunction. Dapoxetine, por otro lado, is a fast-acting SSRI. It is rapidly absorbed and eliminated from the body within a few hours. This favorable pharmacokinetics minimizes the risk of the drug’s accumulation in the body, and therefore reducing side effects.