Exendin-4
Alias: Exenatide Acetate
N° CAS: 141758-74-9
EINECS: 204-035-4
Stockage: Ombres, conservation confinée
Formule moléculaire: C184H282N50O60 S
Masse moléculaire: 4186.66
Pureté :99%min
Apparence: poudre blanche
Minimum order quantity: 2mg/flacon
Supply Ability: Mass stock
Packaging Details: 2mg/5mg/10mg per vial
Usage: Exenatide Acetate can be used to facilitate glucose control.
La description:
Un peptide de 39 acides aminés initialement isolé des glandes salivaires du monstre de Gila (Une hélodermie est suspectée), ne diffère de l'exendine-3 que dans deux positions proches de l'extrémité N-terminale. L'application d'Exenatide provoque une augmentation de l'AMPc acineux sans stimuler la libération d'amylase. En tant que mimétique des incrétines, L'exénatide agit comme agoniste du peptide-1 de type glucagon (GLP-1) récepteur. Comme GLP-1, though with prolonged activity, Exenatide augments the postprandial production of insulin and suppresses secretion of glucagon. For this reason, Exenatide has found use as a medication of diabetes II.
Application:
Exenatide is believed to facilitate glucose control in at least five ways:
1. Exenatide augments pancreas response and more appropriate amount of insulin that helps lower the rise in blood sugar from eating.
2. Exenatide also suppresses pancreatic release of glucagon, which prevents hyperglycemia (high blood sugar levels).
3. Exenatide helps slow down gastric emptying and thus decreases the rate at which meal-derived glucose appears in the bloodstream.
4. Exenatide has a subtle yet prolonged effect to reduce appetite, promote satiety via hypothalamic receptors.
5. Exenatide reduces liver fat content. Fat accumulation in the liver or nonalcoholic fatty liver disease (NAFLD) is strongly related with several metabolic disorders.
