Acetato de Exenatida CAS:141758-74-9

Descrição:

Um peptídeo de 39 aminoácidos originalmente isolado das glândulas salivares do monstro Gila (Suspeita-se de heloderma), difere da exendina-3 apenas em duas posições próximas ao terminal N. A aplicação de Exenatida causa aumento do AMPc acinar sem estimular a liberação de amilase. Como um mimético de incretina, A exenatida atua como agonista do peptídeo-1 semelhante ao glucagon (GLP-1) receptor. Como GLP-1, though with prolonged activity, Exenatide augments the postprandial production of insulin and suppresses secretion of glucagon. For this reason, Exenatide has found use as a medication of diabetes II.

Inscrição:

Exenatide is believed to facilitate glucose control in at least five ways:

1. Exenatide augments pancreas response and more appropriate amount of insulin that helps lower the rise in blood sugar from eating.

2. Exenatide also suppresses pancreatic release of glucagon, which prevents hyperglycemia (high blood sugar levels).

3. Exenatide helps slow down gastric emptying and thus decreases the rate at which meal-derived glucose appears in the bloodstream.

4. Exenatide has a subtle yet prolonged effect to reduce appetite, promote satiety via hypothalamic receptors.

5. Exenatide reduces liver fat content. Fat accumulation in the liver or nonalcoholic fatty liver disease (NAFLD) is strongly related with several metabolic disorders.