Eş anlamlı: 4-Androstenedione(4Reklam); 3,17-Dioxoandrost-4-Ene;delta-(sup4)-Androsten-3,17-dione;delta(Sup4)-Androstene-3,17-dione;delta4-androsten-3,17-dione;delta-4-androstenedione;SKF 2170;skf2170;4-Reklam
CAS: 63-05-8
MF: C19H26O2
MW: 286.41
EINECS: 200-554-5
Saflık: 98.88%
Manufacturer: Doublewin
Characters: Near white crystalline powder, soluble in ethanol, suda çözünmez
Androstenedion, erkek ve kadın cinsiyet hormonlarının ortak öncüsüdür.. Androstenedionun bir kısmı da plazmaya salgılanır., ve periferik dokularda testosteron ve östrojenlere dönüştürülebilir.
Androstenedion iki yoldan biriyle sentezlenebilir. Birincil yol, 17-hidroksipregnenolon'un 17,20-liyaz yoluyla dehidroepiandrosterona dönüştürülmesini içerir., with subsequent conversion ofdehydroepiandrosterone to androstenedione via the enzyme 3-β-hydroxysteroid dehydrogenase. The secondary pathway involves conversion of 17-hydroxyprogesterone, most often a precursor to cortisol, to androstenedione directly by way of 17,20-lyase. Böylece, 17,20-lyase is required for the synthesis of androstenedione, whether immediately or one step removed.
The production of adrenal androstenedione is governed by ACTH, whereas production of gonadal androstenedione is under control by gonadotropins. In premenopausal women, the adrenal glands and ovaries each produce about half of the total androstenedione(about 3 mg/gün). After menopause, androstenedione production is about halved, due primarily to the reduction of the steroid secreted by the ovary. Yine de, androstenedione is the principal steroid produced by the postmenopausal ovary.
