Sinônimos: 4-Androstenedione(4ANÚNCIO); 3,17-Dioxoandrost-4-Ene;delta-(sup4)-Androsten-3,17-dione;delta(Sup4)-Androstene-3,17-dione;delta4-androsten-3,17-dione;delta-4-androstenedione;SKF 2170;skf2170;4-ANÚNCIO
CAS: 63-05-8
MF: C19H26O2
MW: 286.41
EINECS: 200-554-5
Pureza: 98.88%
Manufacturer: Doublewin
Characters: Near white crystalline powder, soluble in ethanol, insoluble in water
Androstenediona é o precursor comum dos hormônios sexuais masculinos e femininos. Alguns Androstenediona também é secretada no plasma, e pode ser convertido em tecidos periféricos em testosterona e estrogênios.
Androstenediona pode ser sintetizado de uma de duas maneiras. A via primária envolve a conversão de 17-hidroxipregnenolona em desidroepiandosterona por meio de 17,20-liase, with subsequent conversion ofdehydroepiandrosterone to androstenedione via the enzyme 3-β-hydroxysteroid dehydrogenase. The secondary pathway involves conversion of 17-hydroxyprogesterone, most often a precursor to cortisol, to androstenedione directly by way of 17,20-lyase. Desta forma, 17,20-lyase is required for the synthesis of androstenedione, whether immediately or one step removed.
The production of adrenal androstenedione is governed by ACTH, whereas production of gonadal androstenedione is under control by gonadotropins. In premenopausal women, the adrenal glands and ovaries each produce about half of the total androstenedione(about 3 mg/dia). After menopause, androstenedione production is about halved, due primarily to the reduction of the steroid secreted by the ovary. No entanto, androstenedione is the principal steroid produced by the postmenopausal ovary.
