Takrolimus CAS:104987-11-3

Takrolimus, även känd som fujimycin, är ett immunsuppressivt läkemedel som främst används efter allogen organtransplantation för att minska risken för organavstötning. Det uppnår detta genom att hämma produktionen av interleukin-2, en molekyl som främjar utvecklingen och spridningen av T-celler, som är avgörande för kroppens inlärning (eller adaptiv) immunsvar.

Tacrolimus is also used in the treatment of other T cell-mediated diseases such as eczema (for which it is applied to the skin in a medicated ointment), severe refractory uveitis after bone marrow transplants, exacerbations of minimal change disease, Kimura’s disease, and the skin condition vitiligo.

Tacrolimus is used together with other medicines to prevent the body from rejecting a transplanted organ. This medicine may be used with steroids, azathioprine, basiliximab, or mycophenolate mofetil. Tacrolimus belongs to a group of medicines known as immunosuppressive agents.

Tacrolimus is a very strong medicine. It can cause side effects that can be very serious, such as kidney problems. It may also decrease the body’s ability to fight infections. You and your doctor should talk about the benefits of this medicine as well as the risks of using it. Tacroz Forte Ointment (Takrolimus) is used to treat atopic dermatitis (more commonly known as eczema). It is a topical medication which is normally prescribed for patients who have not responded successfully to other eczema medication.

The ointment is a type of topical calcineurin inhibitor (TCIs) that works by weakening the patient`s immune system, which as a consequence directly reduces the severity of eczema and its symptoms. It should not be used by patients who have any kind of weak immune system.