Октреотида ацетат CAS:83150-76-9

Применение : октреотида ацетат, в качестве инъекционной формы депо для лечения опухолей, продуцирующих гормон роста. (акромегалия и гигантизм).

Описание :

Октреотид (Торговое название Сандостатин, Новартис Фармасьютикалс) представляет собой октапептид, который фармакологически имитирует природный соматостатин., хотя это более мощный ингибитор гормона роста, глюкагон, и инсулин, чем природный гормон. Впервые он был синтезирован в 1979 by the chemist Wilfried Bauer.

заявка :

Octreotide has also been used off-label for the treatment of severe, refractory diarrhea from other causes. It is used in toxicology for the treatment of prolonged recurrent hypoglycemia after sulfonylurea and possibly meglitinides overdose. It has also been used with varying degrees of success in infants with nesidioblastosis to help decrease insulin hypersecretion.

Octreotide has been used experimentally to treat obesity, particularly obesity caused by lesions in the hunger and satiety centers of the hypothalamus, a region of the brain central to the regulation of food intake and energy expenditure. The circuit begins with an area of the hypothalamus, the arcuate nucleus, that has outputs to the lateral hypothalamus (левый) and ventromedial hypothalamus (VMH), the brain’s feeding and satiety centers, respectively. The VMH is sometimes injured by ongoing treatment for acute lymphoblastic leukemia (ALL) or surgery or radiation to treat posterior cranial fossa tumors.