17 Alpha hydroxyprogesterone
Nomen chemicum: 17-Alpha, hydroxypregn, IV-Eythus-3,20, Dione
Formulae hypotheticae: C21H30O3
M. pondus: 330.47
CAS non.: 68-96-2
Aspectus: Alba et fere album crystalline pulveris
Assay: ≥99.0%
Point liquescens: ≥214 ° C
17-Hydroxyprogesterone (17-Ohp) est endogenous progestogen tum chemical medium in biosynthesisof othersteroid hormones, inter corticosteroids et androgens et estrogens.
Est ex progesterone via XVII-hydroxylase, A P450C17 enzyme, aut ex XVII-hydroxypregnenolone via III-hydroxysteroid dehydrogenase isomerase.
17-OHP crescit in tertio trimester of graviditate praesertim ex foetus adrenal production.This steroid est praesertim produci in adrenal glandulis et ad aliquid gradu in gonads, In specie Corpus luteum ovarium. Normalis campester sunt 3-90 NG / DL in filios, et in mulieribus, 20-100 NG / DL prior ad ovulation, et 100-500 NG / DL in Thelelutei Phase.
Hormone XVII-hydroxyprogesterone est aedificium obstructionum ad producendo hormone cortisol. Cortisol produci maxime per adrenal cortex (ad exteriores pars duorum adrenal glandulis, sita super renes). Cortisol dicitur quod “accentus hormone” Quia suus 'secretus in maius amounts ut pars corporis responsio ad corporalis vel motus stress.in haedos, maxime causa cortisol defectus, Et ideo princeps campester of XVII-hydroxyprogesterone, unum ex formis geneticae inordia congenital adrenal hyperplasia (CAH).
17-hydroxyprogesterone est elevatur in aegris cum congenita adrenal hyperplasia (CAH). CAH est coetus autosomal recessive morbos propria per defectus cortisol et excessus ACTH. 17-hydroxyprogesterone est etiam utilis in Cortisol Cortisol postea Lorem et in aestimandis infecunditate et adrenal et ovarian Neoplasms.
