CAS: 168273-06-1
فرمول مولکولی: C22H21Cl3N4O. ClH
وزن مولکولی: 500.25
ظاهر: White or almost white crystalline powder
خلوص: ≥ 99% توسط HPLC
نقطه ذوب: 272.25 ℃
استفاده: واسطه های دارویی, fine organic synthesis and catalyst, health care products etc
ریمونابانت (انجام دهد) اولین در دسته جدیدی از عوامل درمانی به نام مسدود کننده های گیرنده کانابینوئید-1 بود (CB1). Acomplia برای استفاده در درمان چاقی و شرایط مرتبط مورد مطالعه قرار گرفت.
یک داروی شگفت انگیز تجربی, ریمونابانت, به کاهش وزن کمک می کند, سیگار را ترک کنید و همچنین به محافظت از قلب شما کمک می کند. آزمایشات نشان داده است 33% از افرادی که در Rimonabant از دست دادند 10% of body weight and kept their weight down for two years – this is a record, no other diet drug has managed to keep a person’s weight down for so long. The second 33% lost 5% of body weight and kept it down. As well as keeping you lean, the drug also helps you quit the smoking habit. This will be of great interest for many smokers who are afraid to give up because they say they will put on loads of weight if they do.
Rimonabant has also been shown to be a μ-opioid receptor antagonist (possibly the contributing factor in its reported dysphoric qualities).Its main effect is reduction in appetite.
1. Obesity:
In a 2006 (2 year) study reported in JAMA, “Compared with the placebo group, را 20 mg of rimonabant group produced greater mean (SEM) reductions in weight (-6.3kg vs -1.6kg; پ<.001), waist circumference (-6.1cm vs -2.5cm; پ<.001), and level of triglycerides (percentage change, -5.3در مقابل 7.9; پ<.001) and a greater increase in level of high-density lipoprotein cholesterol (percentage change, 12.6در مقابل 5.4; پ<.001).”
2. Smoking cessation:
Rimonabant may also be found to be effective in assisting some smokers to quit smoking. Sanofi is currently conducting studies to determine the possible value of rimonabant in smoking-cessation therapy. The Studies with Rimonabant and Tobacco Use (STRATUS) program involves more than 6,000 subjects.
STRATUS is designed to explore two smoking-related therapies: first, to use rimonabant directly to aid in smoking cessation; second, to help prevent weight gain in former smokers. Initial results apparently suggest rimonabant is effective for both uses. با این حال, the FDA has explicitly stated to Sanofi that, without additional studies, rimonabant cannot be approved in the United States for smoking cessation therapy.
