Abiraterone Acetate CAS:154229-18-2

آنتاگونیست های آندروژن. ابیراترون استات (INN, USAN, ممنوعیت, ژان) (نام های تجاری Zytiga, ابیرات, آبروتون, Abirapro) یک آنتی آندروژن استروئیدی است, به طور خاص یک مهارکننده سنتز آندروژن, در ترکیب با سرطان پروستات مقاوم به اخته متاستاتیک استفاده می شود (قبلاً سرطان پروستات مقاوم به هورمون یا مقاوم به هورمون نامیده می شد) – یعنی, سرطان پروستات به محرومیت آندروژن یا درمان با آنتاگونیست های گیرنده آندروژن پاسخ نمی دهد. It is a prodrug to the active agent abiraterone, and is marketed by Janssen Biotech under the trade name Zytiga. علاوه بر این, Intas Pharmaceuticals markets the drug under the trade name Abiratas, Cadila Pharmaceuticals markets the drug as Abretone, and Glenmark Pharmaceuticals as Abirapro.

Abiraterone acetate was approved by the United States Food and Drug Administration on April 28, 2011. The FDA press release made reference to a phase III clinical trial in which abiraterone use was associated with a median survival of 14.8 months versus 10.9 months with placebo; the study was stopped early because of the successful outcome.

Use in Cancer Abiraterone acetate is approved to be used with to treat Prostate cancer that has metastasized (spread to other parts of the body). It is used in patients whose disease has not gotten better with other hormone therapy.Abiraterone is also being studied in the treatment of other types of cancer.