Desmopressin Acetate
Alias : Sodium deoxyribose cytidylic acid,Davp
Cas No. : 16789-98-3
Molekylär formel : C46H64N14O12S2
Molekylvikt :1189.32
Renhet (HPLC) : 98.0%min.
Utseende : vitt pulver
Single Impurity (HPLC) : 0.5%max
Amino Acid Composition : ±10% of theoretical
Peptide Content (N%) : ≥80.0%
Water Content (Karl Fischer) : ≤8.0%
Acetate Content (HPIC) : ≤12.0%
Mass Balance : 95.0~105.0%
Lagring: Closed, below 2 ~ 8°C preservation
Användande : Desmopressinacetat används för nattlig enures, koagulationsrubbningar och diabetes insipidus.
Beskrivning:
Desmopressin (handelsnamn: Davp, DesmoMelt, Minirin, Minirin Smält, Octim, Kär) är en syntetisk ersättning för vasopressin, hormonet som minskar urinproduktionen. Det kan tas nasalt, intravenöst, eller som en oral eller sublingual tablett. Läkare ordinerar desmopressin oftast för behandling av diabetes insipidus, bedwetting, or nocturia.
Ansökan :
Doctors prescribe desmopressin frequently for treatment of nocturnal enuresis (bedwetting). It is usually prescribed in the form of oral desmopressin acetate, Davp. Patients taking DDAVP are 4.5 times more likely to sleep without disruption compared with placebo.
Desmopressin can be used to promote the release of von Willebrand factor (with subsequent increase in factor VIII survival secondary to vWF complexing) in patients with coagulation disorders such as von Willebrand disease, mild hemophilia A (factor VIII deficiency), and thrombocytopenia. It can be used with uremic induced platelet dysfunction. It is not effective in the treatment of hemophilia B (factor IX deficiency), severe hemophilia A, or von Willebrand.
Desmopressin is used in the treatment of central diabetes insipidus (DI), to replace endogenous ADH that is missing in the central nervous system type of this disorder (decreased production of ADH from the posterior pituitary). It is also used in the diagnostic workup for diabetes insipidus, in order to distinguish central from nephrogenic DI.
