Melanotan I CAS:75921-69-6

1.MT-1 (aut Melanotan I,aut Afamelanotide,aut CUV-1647) Est synthetica analogon peptidum naturae endogenosi peptidis melanocortini alpha-melanocyte hormone excitantis. Habet hormones naturam sicut communes proteins.Metallothioneins(MTs) Sunt cysteino-dives metalli ligandi proteins quae potentia involvit zincum homeostasim et liberum radicalem scavenging. Locutio exemplaris MT-1 et activitatis ligationis variarum elementorum MT-1 promotorum investigatum est post lenem focalem ischemiam cerebri in rat.. Ischemia focalis transiens inducebatur ab occludendis arteriis carotidis communibus et arteria cerebri media recta ad 30 min. Per usum real-time quantitatis PCR, ad X duplici incremento in MT-I and -2 variant gradus inventa in cortex 24 hr post reperfusion.

2.Afamelanotida speciatim evoluta est ab phisicis Americanorum ductus a V.Hruby in 1991 as a possible research compound that can be used against skin cancer by stimulating tanning system which in own turn would generate protective natural tan during melanogenesis.So that synthetic analog was created to determine if it can show the same effect and stimulate melanocytes to produce and release melanin to protect skin from UV.Most of studies and trials were conducted in United States and Australia.

3.Developed research compound is quite stable cyclic form of original hormone but specifically has much longer half-life period.It works as agonist of specific melanocortin receptor and possesses such property as being selective;And thus it promotes increased level of eumelanin above usual pheomelanin,which provides higher efficacy of photoprotection abilities.

4.Melanotan-I is a synthetic hormone that is stimulating the release of melanocyte-hormone in animal cells. These melanocyte-hormones are the ones responsible for the pigmentation of the skin due to their interaction with melanocortin-1 receptors in the epidermis. These hormones are being released from the pars intermedia of the pituitary glands in some of the eukaryotic animal species. tamen, these are also prominent in the keratinocytes and the melanocytes of the human skin.